Mother–child transmission of epigenetic information by tunable polymorphic imprinting
نویسندگان
چکیده
منابع مشابه
Genomic imprinting and epigenetic control of development.
Epigenetic mechanisms are extensively utilized during mammalian development. Specific patterns of gene expression are established during cell fate decisions, maintained as differentiation progresses, and often augmented as more specialized cell types are required. Much of what is known about these mechanisms comes from the study of two distinct epigenetic phenomena: genomic imprinting and X-chr...
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Genomic imprinting refers to an epigenetic mark that distinguishes parental alleles and results in a monoallelic, parental-specific expression pattern in mammals. Few phenomena in nature depend more on epigenetic mechanisms while at the same time evading them. The alleles of imprinted genes are marked epigenetically at discrete elements termed imprinting control regions (ICRs) with their parent...
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The expression of the H19 gene is governed by parental imprinting in mammals. H19, an unusual gene encoding an RNA with no known function, is exclusively expressed from the maternal chromosome. In mouse, it lies 90 kb downstream from the Igf2 gene, which encodes a fetal-specific growth factor, insulin-like growth factor II, and is expressed primarily from the paternally inherited chromosome. In...
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A growing corpus of data indicates that epigenetic mechanisms regulate sleep and sleep-wake cycles. Here, I discuss recent evidence showing that genomic imprinting, an epigenetic mechanism that regulates parent-of-origin effects in mammals, is involved in the control of rapid eye movement (REM) sleep. REM sleep is an evolutionarily recent form of sleep that is characterized by important electro...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2018
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1815005115